Funded Projects

hotel2
PROJECT

4th Joint Call: ROBTI

The proposal aims to create a distributed bidirectional cross-reputation rating and review service for hotel and tourism industry that can be used through multiple countries, in transboundary transactions, for sustainable, cooperative business. ROBTI is thus in pursuit of several specific objectives (SOs).
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Background

Contemporary hospitality industry faces difficulties maintaining reputation, which is vital for South East Asia where quality and responsible customers are needed in times of tourism boom and looming danger of pollution. In fact, the reputation concept has been widely used since old times, in many areas. For example, selecting doctors or dentists based on their reputation constructed by other friends, getting married with a person based on family and friends’ suggestions or selection of university to attend based on reputation constructed by past students etc. In an organized world, institutions and certifications replaced classical “word of mouth”-based reputation, whereas doctors, universities, companies are rated or accredited by individual institutions who are expert and recognized by the government and trusted as accrediting institutions.

Yet, the ever increasing power of internet, social media and user generated content, revived centuries old “word of mouth”-based reputation. This, on the other hand brings its own special problems to tackle. Vast amount of data generated turns into a big data problem to be solved and processed, whereas credibility of each user generated data becomes questionable. Users, generate star ratings, comments, stories, blogs, tweets and many different content about the experience they had from the service or goods. These are usually incomplete, varying in quality and credibility and vague in general. This in turn increases the pressure onto the emerging forms of cooperative sustainable tourism that does not have the solid market power of multinational chains.

 

The project

The proposal aims to create a distributed bidirectional cross-reputation rating and review service for hotel and tourism industry that can be used through multiple countries, in transboundary transactions, for sustainable, cooperative business. ROBTI is thus in pursuit of several specific objectives (SOs):

  • Prototyping software algorithms that validate research on cross-reputation rating and review service for the hospitality sector, blockchain and cooperatives.
  • Combining together holistically concepts and approaches from disciplines in computer science, urbanism, environmental studies, tourism science, and management.
  • Creating an integrated decentralised system for rating and review ready for demonstration and validation in tourism.
  • Contributing to the transformation of the hospitality industry into sustainable, inclusive, cooperative model of transboundary business that is rated by trustworthy distributed rating.

The science

 ROBTI is aligned with concepts such as sustainability and climate-resilience applied to the tourism industry. It aims to combine other aspects of the project with making the hotel business ‘greener’: reducing the carbon imprint of the hospitality sector onto the environment, hotels shall also build resilience in the local community of the tourism destination to disasters. The research by STMIK and further studies to be done within the project will enable disaster resilient hotels to become major catalysts in managing disasters in the destination area.

ROBTI combines studies and applied research about ICT tools for payments of transboundary transactions and cooperative tourism operations, blockchain technology for distributed review and ranking in the tourism industry and machine learning for trust rate calculation, natural language processing and sentiment analysis. To that extent, the industrial partners (Protel and Setur) and Gebze Techical University have previous research that the project will build upon.

The team

The ROBTI partners are:

Alphan Kimyonok (Coordinator), Meltem Turhan Yöndem, Cenk Yusuf Ustabaş, Müslim Erdal Şekerci, Anıl Özdemir, Mustafa Çelen, İsa Öztürk, Setur, Turkey

Hüseyin Atun, Hakan Özkırım, Tolga Gezginiş, Hasan Soysal, Batuhan, Çoşkun, Protel, Turkey

Assoc. Prof. Mehmet Göktürk, Gebze Techncical University, Turkey

Tri A. Sundara, STMIK Indonesia Padang, Indonesia

 

Contact:

Cenk Yusuf Ustabaş         

antibi
PROJECT

4th Joint Call: TIC-TAC

The current antibiotic crisis represents a global problem of fundamental importance, comparable with other global challenges as e.g. climate change or sustainable energetics, but far less discussed in the society. Without active approach right now the, the infectious diseases will soon become the most frequent cause of death worldwide.

The TIC-TAC project consists of two objectives aiming to avert the threat of an antibiotic crisis: 1) Knowledge-based hunt for novel bioactive metabolites derived from plants and microorganisms and 2) Development of promising compounds into drugs.
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Background

The current antibiotic crisis represents a global problem of fundamental importance, comparable with other global challenges as e.g. climate change or sustainable energetics, but far less discussed in the society. Without active approach right now the, the infectious diseases will soon become the most frequent cause of death worldwide.

The TIC-TAC project consists of two objectives aiming to avert the threat of an antibiotic crisis: 1) Knowledge-based hunt for novel bioactive metabolites derived from plants and microorganisms and 2) Development of promising compounds into drugs.

 

The project

Within the Objective 1 we will create a collection of 1000+ unique Actinobacteria strains, a corresponding number of culture broth crude extracts, and 100+ plant crude extracts. Metabolites in the crude extracts will be separated into 5000+ fractions and these will be tested for a broad spectrum of biological activities, particularly against clinically important pathogenic microorganisms (including MDR strains). These include Mycobacterium tuberculosis (causing tuberculosis), G- bacteria, Plasmodium falciparum (causing malaria), Zika virus, and others.

The Objective 2 aims to the development of previously patented hybrid lincosamide derivatives developed by the Czech team and further compounds suggested by SEA teams into drugs.

The science

Our strategy to combat the antibiotic (antibacterial and antiparasitic) crisis exploits natural products that proved to be a superior source of druggable compounds. We will use modern biology and chemistry methodology for this purpose – knowledge-based genome mining (oriented on the search for biosynthetic pathways utilizing alkyl-proline derivatives, which are far more efficient when compared to L-proline incorporating compounds), mass spectrometry-based metabolomics (GNPS molecular networking + other bioinformatics tools); and we will focus on testing multiple targets, i.e. multiple pathogens including those clinically most important and threatening. CZ team will provide a collection of the clinically most dangerous bacterial strains from the WHO list for antimicrobial activity testing; Thai team possess a collection of P. falciparum strains for antimalarial properties and resistant M. tuberculosis strains for antimicrobial properties testing. Unique sources of bioactive metabolites from yet underexplored Thai and Indonesian biotopes will be used to search for new compounds.

 

Project partners:

Institute of Microbiology, Czech Academy of Sciences, Czech Republic (PI and main coordinator - Jiri Janata)

School of Pharmacy, Walailak University, Thailand  (PI and coordinator for SEA - Amit Jaisi)

Faculty of Pharmacy, Andalas University, West Sumatra, Indonesia (Deri Dachriyanus)

Research Centre for Chemistry, Indonesian Institute of Science (LIPI), Indonesia (Abdi Wira Septama)

 

Contact:

Jiri Janata, Ph.D.                   

tuber
PROJECT

4th Joint Call: SMART-TB

Tuberculosis (TB) remains an urgent public health threat and a leading infectious cause of death worldwide. The SMART TB project propose a novel app that will not only screen patients who are being non-adherent, but will also guide healthcare providers to identify patients’ individual problem and to deliver the recommended personalized strategies
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Background

Tuberculosis (TB) remains an urgent public health threat and a leading infectious cause of death worldwide. Despite long-term support such as directly observed treatment to help patients complete their treatment, non-adherence to TB treatment is known to be suboptimal which leads to treatment failures, poor quality of life, or development of multidrug-resistant tuberculosis. The reasons underlying non-adherence are not entirely independent and are heterogeneous. Digital interventions are gradually being integrated into practice because of affordable mobile electronic devices in many settings. However, the flaws of some of the existing digital technologies to improve medication adherence are that they are not tailored to patients’ individual problems. The existing apps are commonly delivered as a one-size-fit-all intervention, assuming that the reasons for non-adherence are the same for the patients. We propose a novel app that will not only screen patients who are being non-adherent, but will also guide healthcare providers to identify patients’ individual problem and to deliver the recommended personalized strategies

 

The Project

The aim of this project is to develop a smart-phone application for health care providers that can be used for personalized interventions to improve medication adherence of TB patients (SMART-TB) in Indonesia. The proposed apps can be applied in primary, secondary and tertiary health facilities in Indonesia and can be adapted to other high-TB prevalence countries.

 

The Science

The SMART-TB app will be developed in Bahasa with five main functions, called SIM-CAR functions, as follow: Screening (to identify medication adherence problems in TB patients), Intervening (to intervene in TB patients’ individual problems of medication adherence), Monitoring (to monitor TB patients in taking their medication), Communicating (to communicate about medication adherence among TB officers (pharmacist/ TB programmer), TB patients, and TB experts), and Administrating (to register patient information related to medication adherence until the TB treatment outcomes are measured). In the first year, we will develop a prototype of the SMART-TB. Its content development will be performed through a literature review and qualitative study. In the second year, pilot testing will be conducted to validate the content and implementation of the prototype in a small-scale population representing rural and urban area. In the third year, the content and system of the SMART-TB will be validated based on the results of the pilot testing.

 

The Team

The SMART-TB partners are:

  • Coordinator: Rizky Abdulah, PhD, Universitas Padjadjaran, Indonesia
  • Prof. Jutti Levita, Universitas Padjadjaran, Indonesia
  • Ivan S. Pradipta, PhD, Universitas Padjadjaran, Indonesia
  • Sofa D. Alfian, M.PH, PharmD, Universitas Padjadjaran, Indonesia
  • Prof. dr. Eelko Hak, University of Groningen, Groningen, the Netherlands
  • Prof. Katja Taxis, University of Groningen, Groningen, the Netherlands
  • Prof. Jan-Willem Alffenaar, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
  • Job F. M. van Boven, PhD, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
  • Prof. Esin Aki Yalcin, Ankara University, Ankara, Turkey
  • Prof. Federico Gago, University of Alcala, Madrid, Spain
  • Ly Le, PhD, Ho Chi Minh City International University, Vietnam

     

Contact: 

Rizky Abdulah, PhD; Email: r.abdulah@unpad.ac.id 

DAADTHEMAC
PROJECT

4th Joint Call: DAADTHEMAC

Neural angiostrongyliasis, the cause of eosinophilic meningitis, is a consequence of the migration of larvae of the nematode parasite (rat lungworm) Angiostrongylus cantonensis in humans and animals. Resulting disease, termed also Angiostrongylus Eosinophilic Meningitis (AEM) is considered a prominent Emerging Infectious Disease.
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Background

Angiostrongylus cantonensis is a unique pathogen that is predominantly dependent on invasive rodent and mollusc hosts. Continuing spread of these organisms has led to wide distribution of AEM throughout the tropics. The majority of clinical cases are reported from SE Asia (the highest incidence in Thailand), however, the disease is broadly distributed in Pacific regions (French Polynesia, Hawaii, Australia) with recent invasions into continental USA. Recently, the pathogen was discovered in rats in the Canary Islands and two year ago, clinical human AEM cases were reported in France. Most recently, in 2019, the parasite was detected in Mallorca, Spain, demonstrating immediate risk of spread in southern parts of EU territories.

 

The Project

This project aims to develop a novel diagnostic tool for human eosinophilic meningitis caused by Angiostrongylus cantonensis, namely a LAMP assay for AC detection in clinical cases, in various organism that serve as infection sources and in environmental samples. Our project consortium combines teams with expertise in various fields of human and veterinary medicine, ecology and infection biology. Project benefits from experience of EU and Thailand teams with development of molecular-based diagnostic tools including the LAMP technology, equipment and experimental work with AC, combined with partnerships/collaboration with research teams from countries with high incidences of AEM clinical cases in SE Asia (Philippines, Thailand, Indonesia). With synergic involvement of adjunct research partners from Australia, Spain, Italy and UK, the project team aims at (i) technological progress in AEM clinical diagnostics, (ii) detection of AC in food chains and (iii) understanding of local as well as global epidemiology of this emerging disease.

 

The Science

As the epidemiology of AEM involves humans, various mammals and birds, invertebrates, as well as environmental components, the One Health approach represents an ultimate avenue in diagnostics and prevention of this emerging disease.  As a result, composition of the consortium, the project involves experimental activities associated with development, optimization and experimental testing of developed assays, alongside clinical evaluation in medical facilities in SEA and detection of AC in the food chain and environment. Proposed LAMP diagnostics offer a range of advantages over other diagnostic approaches as it is applicable in field and clinical conditions as does not require time consuming and technologically demanding steps. The results of this project can be immediately disseminated and translated into sensitization of local populations and public awareness, respecting given cultural context and stage of development of partnering ASEAN countries.  

 

The Team

  • Prof. David Modry, Dr. Vojto Baláž and Barbora Fecková, DVM / Biology Center of Czech Academy of Sciences v.v.i., České Budějovice, Czech Republic

 

  • Muhammad Hambal, DVM, Ph.D. / Syiah Kuala University, Faculty of Veterinary Medicine, Banda Aceh, Indonesia

 

  • Prof. Jan Slapeta / University of Sydney, School of Veterinary Science, Sydney, Australia

 

  • Prof. Domenico Otranto / University of Bari, Department of Veterinary Medicine, Bari, Italy

 

  • Prof. Pilar Foronda Rodríguez / Universidad de La Laguna, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Spain

 

  • Dr. Nicholas Morant, OptiGene Limited, Horsham, UK

 

Contact

Prof. MVDr. David Modry, Ph.D. / Biology Center of Czech Academy of Sciences, České Budějovice, Czech Republic

email: modrydav@gmail.com